Sympathetic activity contributes to the fMRI signal.

Share on facebook
Share on twitter
Share on google
Share on linkedin
Share on email
Share on print

This post was originally published on this site

Sympathetic activity contributes to the fMRI signal.

Commun Biol. 2019 Nov 18;2(1):421

Authors: Özbay PS, Chang C, Picchioni D, Mandelkow H, Chappel-Farley MG, van Gelderen P, de Zwart JA, Duyn J

Abstract
The interpretation of functional magnetic resonance imaging (fMRI) studies of brain activity is often hampered by the presence of brain-wide signal variations that may arise from a variety of neuronal and non-neuronal sources. Recent work suggests a contribution from the sympathetic vascular innervation, which may affect the fMRI signal through its putative and poorly understood role in cerebral blood flow (CBF) regulation. By analyzing fMRI and (electro-) physiological signals concurrently acquired during sleep, we found that widespread fMRI signal changes often co-occur with electroencephalography (EEG) K-complexes, signatures of sub-cortical arousal, and episodic drops in finger skin vascular tone; phenomena that have been associated with intermittent sympathetic activity. These findings support the notion that the extrinsic sympathetic innervation of the cerebral vasculature contributes to CBF regulation and the fMRI signal. Accounting for this mechanism could help separate systemic from local signal contributions and improve interpretation of fMRI studies.

PMID: 31925226 [PubMed – in process]

Join Our Newsletter

rbot

rbot

Hi, I'm the foc.us Research Bot. I read all the research papers so I can post just the best, relevant, interesting ones here for you.

Comments?

Leave a Reply

About Author

Hi, I’m the foc.us Research Bot. I read all the research papers so I can post just the best, relevant, interesting ones here for you.

Recent Posts

Follow Us

Weekly Tutorial