The Efficacy and Safety of Rapid Cycling Vagus Nerve Stimulation

Link – The Efficacy and Safety of Rapid Cycling Vagus Nerve Stimulation in Children With Intractable Epilepsy. Abstract PURPOSE: Vagus nerve stimulation (VNS) is an effective adjunctive therapy for drug-resistant epilepsy. Nevertheless, information is lacking regarding optimization of stimulation parameters to improve efficacy. Our study examines the safety and efficacy of rapid duty cycle VNS […]

Rat vagus nerve stimulation parameters

Link – Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects. Abstract BACKGROUND: Recent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied VNS parameters. OBJECTIVE: To allow meaningful preclinical research on the mechanisms of VNS and translation […]

Vagal Nerve Stimulation in Epilepsy

Link – Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits. Abstract Introduction: The purpose of this study was to examine patients’ experiences of vagal nerve stimulation (VNS) with a special interest in patients with cognitive deficit (CD). Materials and Methods: An open, retrospective study was conducted on 82 patients with pharmacoresistant epilepsy, […]

Finite element modeling of compound peripheral nerves.

Link – On the parameters used in finite element modeling of compound peripheral nerves. Abstract OBJECTIVE: Computational modeling is an important tool for developing and optimizing implantable neural stimulation devices, but requires accurate electrical and geometrical parameter values to improve predictive value. We quantified the effects of perineurial (resistive sheath around each fascicle) and endoneurial […]

Epilepsy patients treated with Vagus Nerve Stimulation

Link – Neurophysiological investigations of drug resistant epilepsy patients treated with Vagus Nerve Stimulation to differentiate responders from non-responders. Abstract BACKGROUND: In patients treated with vagus nerve stimulation (VNS) for drug resistant epilepsy (DRE), up to 1/3 of patients will eventually not respond to the therapy. As VNS therapy requires surgery for device implantation, prediction […]

Vagus nerve stimulation parameters alter inflammation.

Link – Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation. Abstract Background: Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacious symptomatic relief depends on the proper selection of […]

Transcutaneous vagal nerve stimulation improves gastroenteric complaints

Link – Transcutaneous vagal nerve stimulation improves gastroenteric complaints in Parkinson’s disease patients. Abstract BACKGROUND: Gastrointestinal dysfunctions are common in Parkinson’s disease. Their management is still challenging and new treatment options are needed. OBJECTIVE: To test whether transcutaneous vagal nerve stimulation can improve gastrointestinal dysfunction in patients with Parkinson’s disease. METHODS: We performed a randomized […]

Potential biomarkers for transcutaneous vagus nerve stimulation.

Link – Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation. Abstract Transcutaneous vagus nerve stimulation (tVNS) is a non-invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood and it […]

Sensitivity Study of Auricular Vagus Nerve Stimulation.

Link – Sensitivity Study of Neuronal Excitation and Cathodal Blocking Thresholds of Myelinated Axons for Percutaneous Auricular Vagus Nerve Stimulation. Abstract OBJECTIVE: Excitation of myelinated nerve fibers is investigated by means of numerical simulations, for the application of percutaneous auricular vagus nerve stimulation (pVNS). High sensitivity to axon diameter is of interest regarding the goal […]

Transcutaneous Vagus Nerve Stimulation to Suppress Atrial Fibrillation

Link – Related Articles TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation): A Randomized Clinical Trial. Abstract OBJECTIVES: This study was a sham-controlled, double-blind, randomized clinical trial to examine the effect of chronic low level tragus stimulation (LLTS) in patients with paroxysmal AF. BACKGROUND: Low-level transcutaneous electrical stimulation of the auricular branch […]