Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury

Link – Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB/NLRP3 Signaling Pathway. Abstract BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Oxidative stress, inflammation, and apoptosis are vital pathophysiological features post-TBI. OBJECTIVES: Research has shown that vagus nerve stimulation (VNS) can attenuate oxidative stress in […]

tVNS prevents oesophageal pain hypersensitivity.

Link – Transcutaneous vagus nerve stimulation prevents the development of, and reverses, established oesophageal pain hypersensitivity. Abstract BACKGROUND: The vagus nerve exerts an anti-nociceptive effect in the viscera. AIMS: To investigate whether transcutaneous vagal nerve stimulation (t-VNS) prevents the development and/or reverses established visceral hypersensitivity in a validated model of acid-induced oesophageal pain. METHODS: Before […]

Anti-inflammatory effects of electrical stimulation

nathan whitmore and his rats

Link – Autonomically mediated anti-inflammatory effects of electrical stimulation at acupoints in a rodent model of colonic inflammation. Abstract BACKGROUND: Acupuncture has been widely accepted for treatments of many diseases. This study was performed to determine effects and mechanisms of electroacupuncture (EA) by chronically implanted electrodes at acupoint ST36 on colonic inflammation induced by TNBS […]

Vagus Nerve Stimulation in Patients with Covid-19?

Corona Virus

Link – Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19? Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some critical patients with COVID-19. This storm is due to the release of high levels of […]

Non-invasive vagus nerve stimulation for headache

Link – Non-invasive vagus nerve stimulation for primary headache: A clinical update. Abstract BACKGROUND: Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster headache and migraine. Several possible mechanisms of action by which nVNS mitigates headache have been identified. METHODS: We conducted a narrative review of recent scientific and clinical research into nVNS […]

Vagus nerve stimulation reduces spreading depolarization burden

nathan whitmore and his rats

Link – Vagus nerve stimulation reduces spreading depolarization burden and cortical infarct volume in a rat model of stroke. Abstract Cortical spreading depolarization (SD) waves negatively affect neuronal survival and outcome after ischemic stroke. We here aimed to investigate the effects of vagus nerve stimulation (VNS) on SDs in a rat model of focal ischemia. […]

Neuromodulation, Specialized Proresolving Mediators, and Pain.

Link – Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain. Abstract The current crises in opioid abuse and chronic pain call for the development of nonopioid and nonpharmacological therapeutics for pain relief. Neuromodulation-based approaches, such as spinal cord stimulation, dorsal root ganglion simulation, and nerve stimulation including vagus nerve stimulation, have shown efficacy in achieving […]

Non-invasive Low-level Tragus Stimulation in Cardiovascular Diseases.

Link – Non-invasive Low-level Tragus Stimulation in Cardiovascular Diseases. Abstract Low-level tragus stimulation (LLTS) is a non-invasive approach of transcutaneous vagus nerve stimulation. LLTS has applications in diseases of multiple systems, including epilepsy, depression, headache and potentially several cardiovascular diseases. LLTS has shown promising results in suppressing AF, alleviating post-MI ventricular arrhythmias and ischaemia-reperfusion injury […]

Recording Vagus Nerve activity in Rats.

nathan whitmore and his rats

Link – Recording of spontaneous vagus nerve activity during Pentylenetetrazol-induced seizures in rats. Abstract BACKGROUND: Vagus nerve stimulation is a treatment for refractory epilepsy. The vagus nerve carries parasympathetic information and innervates multiple organs. As seizures are commonly associated with autonomic manifestations, we believe that biomarkers for diseases affecting autonomic functions such as epilepsy can […]

Sources of off-target effects of vagus nerve stimulation

Link – Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs. Abstract Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by side effects such as cough and dyspnea that have stimulation thresholds lower than those for therapeutic outcomes. VNS side effects are putatively caused by […]