Vagus Nerve Stimulation + Upper-Limb Rehabilitation After Stroke

Link – Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Stroke: One-Year Follow-up. Abstract Background. Vagus nerve stimulation (VNS) paired with rehabilitation may improve upper-limb impairment and function after ischemic stroke. Objective. To report 1-year safety, feasibility, adherence, and outcome data from a home exercise program paired with VNS using long-term follow-up data from a […]

Vagus nerve stimulation paired with tones for tinnitus suppression

Link – Vagus nerve stimulation paired with tones for tinnitus suppression: Effects on voice and hearing. Abstract Objective: In individuals with chronic tinnitus, our interest was to determine whether daily low-level electrical stimulation of the vagus nerve paired with tones (paired-VNSt) for tinnitus suppression had any adverse effects on motor-speech production and physiological acoustics of […]

Vagus nerve stimulation parameters alter inflammation.

Link – Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation. Abstract Background: Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacious symptomatic relief depends on the proper selection of […]

Vagus nerve stimulation parameters on gastric motility

Link – Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging. Abstract BACKGROUND: Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized. METHODS: In anesthetized […]

A neural circuit for mechanosensory control of ingestion in Mice.

Link – A neural circuit mechanism for mechanosensory feedback control of ingestion. Abstract Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut-brain communication pathways and mechanisms remain poorly understood1-12. Here we show that, in mice, neurons in the parabrachial nucleus that express […]

Food Seeking Depends on Vagus-Mediated Neuron Activity

Link – Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity. Abstract Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental […]

Transcutaneous vagal nerve stimulation improves gastroenteric complaints

Link – Transcutaneous vagal nerve stimulation improves gastroenteric complaints in Parkinson’s disease patients. Abstract BACKGROUND: Gastrointestinal dysfunctions are common in Parkinson’s disease. Their management is still challenging and new treatment options are needed. OBJECTIVE: To test whether transcutaneous vagal nerve stimulation can improve gastrointestinal dysfunction in patients with Parkinson’s disease. METHODS: We performed a randomized […]

Treatment of rheumatoid arthritis with a vibrotactile ear clip

Link – Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear. Abstract Background: Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory disease characterized by extensive joint tissue inflammation. Implantable bioelectronic devices targeting the inflammatory reflex reduce TNF production and inflammation in preclinical models of inflammatory disease, and in patients […]

Pulmonary arterial hypertension: the case for a bioelectronic treatment.

Link – Pulmonary arterial hypertension: the case for a bioelectronic treatment. Abstract Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive and vasodilative processes in the pulmonary circulation, pulmonary vasoconstriction, vascular and right ventricular remodeling, systemic […]

Transcutaneous Vagus Nerve Stimulation for Severe Traumatic Brain Injury

Link – Transcutaneous Vagus Nerve Stimulation in Patients With Severe Traumatic Brain Injury: A Feasibility Trial. Abstract OBJECTIVES: Preclinical studies have shown that surgically implanted vagus nerve stimulation (VNS) promotes recovery of consciousness and cognitive function following experimental traumatic brain injury (TBI). The aim of this study is to report the feasibility and safety of […]