tVNS prevents oesophageal pain hypersensitivity.

Link – Transcutaneous vagus nerve stimulation prevents the development of, and reverses, established oesophageal pain hypersensitivity. Abstract BACKGROUND: The vagus nerve exerts an anti-nociceptive effect in the viscera. AIMS: To investigate whether transcutaneous vagal nerve stimulation (t-VNS) prevents the development and/or reverses established visceral hypersensitivity in a validated model of acid-induced oesophageal pain. METHODS: Before […]

taVNS at 20 Hz Improves Depression-Like Behaviors

Link – Transcutaneous Auricular Vagus Nerve Stimulation at 20 Hz Improves Depression-Like Behaviors and Down-Regulates the Hyperactivity of HPA Axis in Chronic Unpredictable Mild Stress Model Rats. Abstract Transcutaneous auricular vagus nerve stimulation (taVNS) has gained growing interest as a non-invasive and non-pharmacologic treatment option in various neurological and psychiatric disorders. Animal experiments and clinical […]

tVNS Improves High-Confidence Recognition Memory

Link – Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing. Abstract Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular […]

Non-invasive vagus nerve stimulation for headache

Link – Non-invasive vagus nerve stimulation for primary headache: A clinical update. Abstract BACKGROUND: Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster headache and migraine. Several possible mechanisms of action by which nVNS mitigates headache have been identified. METHODS: We conducted a narrative review of recent scientific and clinical research into nVNS […]

Neuromodulation, Specialized Proresolving Mediators, and Pain.

Link – Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain. Abstract The current crises in opioid abuse and chronic pain call for the development of nonopioid and nonpharmacological therapeutics for pain relief. Neuromodulation-based approaches, such as spinal cord stimulation, dorsal root ganglion simulation, and nerve stimulation including vagus nerve stimulation, have shown efficacy in achieving […]

Noradrenergic Regulation of Cognitive Flexibility

Link – Noradrenergic Regulation of Cognitive Flexibility: No Effects of Stress, Transcutaneous Vagus Nerve Stimulation, and Atomoxetine on Task-switching in Humans. Abstract Cognitive flexibility allows us to adaptively switch between different responsibilities in important domains of our daily life. Previous work has elucidated the neurochemical basis underlying the ability to switch responses to a previously […]

Non-invasive Low-level Tragus Stimulation in Cardiovascular Diseases.

Link – Non-invasive Low-level Tragus Stimulation in Cardiovascular Diseases. Abstract Low-level tragus stimulation (LLTS) is a non-invasive approach of transcutaneous vagus nerve stimulation. LLTS has applications in diseases of multiple systems, including epilepsy, depression, headache and potentially several cardiovascular diseases. LLTS has shown promising results in suppressing AF, alleviating post-MI ventricular arrhythmias and ischaemia-reperfusion injury […]

Effect of tVNS on Brain Processing of Food Cues

Link – Effect of Short-Term Transcutaneous Vagus Nerve Stimulation (tVNS) on Brain Processing of Food Cues: An Electrophysiological Study. Abstract Background: The vagus nerve plays an important role in the regulation of food intake. Modulating vagal activity via electrical stimulation (VNS) in patients and animal studies caused changes in food intake, energy metabolism, and body […]

tVNS May Enhance Core Executive Functions

Link – Transcutaneous Vagus Nerve Stimulation May Enhance Only Specific Aspects of the Core Executive Functions. A Randomized Crossover Trial. Abstract Background: Individuals are able to perform goal-directed behaviors thanks to executive functions. According to the neurovisceral integration model, executive functions are upregulated by brain areas such as the prefrontal and cingulate cortices, which are […]

A frontal-vagal network theory for Major Depressive Disorder

Link – A frontal-vagal network theory for Major Depressive Disorder: Implications for optimizing neuromodulation techniques. Abstract Major Depressive Disorder (MDD) is a psychiatric disorder characterized by high comorbidity with cardiovascular disease. Furthermore, a combination of high heart rate (HR) and low heart rate variability (HRV) has been frequently reported in depressed patients. The present review […]