Functional Recovery after Experimental Stroke in Rats.

nathan whitmore and his rats

Link – PPAR-γ Mediates Ta-VNS-Induced Angiogenesis and Subsequent Functional Recovery after Experimental Stroke in Rats. Abstract Background: Neoangiogenesis after cerebral ischemia in mammals is insufficient to restore neurological function, illustrating the need to design better strategies for improving outcomes. Our previous study has suggested that transcutaneous auricular vagus nerve stimulation (ta-VNS) induced angiogenesis and improved […]

Anti-inflammatory effects of electrical stimulation

nathan whitmore and his rats

Link – Autonomically mediated anti-inflammatory effects of electrical stimulation at acupoints in a rodent model of colonic inflammation. Abstract BACKGROUND: Acupuncture has been widely accepted for treatments of many diseases. This study was performed to determine effects and mechanisms of electroacupuncture (EA) by chronically implanted electrodes at acupoint ST36 on colonic inflammation induced by TNBS […]

Electrophysiological Effects of tDCS in Rats

nathan whitmore and his rats

Link – Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex. Abstract Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates the neuronal membrane potential. We have previously documented a sustainable increase in extracellular dopamine levels in the rat striatum of cathodal tDCS, suggesting that cathodal tDCS […]

Vagus nerve stimulation reduces spreading depolarization burden

nathan whitmore and his rats

Link – Vagus nerve stimulation reduces spreading depolarization burden and cortical infarct volume in a rat model of stroke. Abstract Cortical spreading depolarization (SD) waves negatively affect neuronal survival and outcome after ischemic stroke. We here aimed to investigate the effects of vagus nerve stimulation (VNS) on SDs in a rat model of focal ischemia. […]

Open-source stimulator for tES in Rats

nathan whitmore and his rats

Link – Open-tES: An open-source stimulator for transcranial electrical stimulation designed for rodent research. Abstract Non-invasive neuromodulatory techniques, including transcranial direct current stimulation (tDCS), have been shown to modulate neuronal function and are used both in cognitive neuroscience and to treat neuropsychiatric conditions. In this context, animal models provide a powerful tool to identify the […]

Recording Vagus Nerve activity in Rats.

nathan whitmore and his rats

Link – Recording of spontaneous vagus nerve activity during Pentylenetetrazol-induced seizures in rats. Abstract BACKGROUND: Vagus nerve stimulation is a treatment for refractory epilepsy. The vagus nerve carries parasympathetic information and innervates multiple organs. As seizures are commonly associated with autonomic manifestations, we believe that biomarkers for diseases affecting autonomic functions such as epilepsy can […]

Vagus nerve stimulation on glycemia

Link – Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions. Abstract Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the effect various electrical vagus nerve stimulation strategies have on glycemia and glucose-regulating hormones, as a first […]

Vagus nerve stimulation in the sensory cortex of rats.

nathan whitmore and his rats

Link – Vagus nerve stimulation (VNS)-induced layer-specific modulation of evoked responses in the sensory cortex of rats. Abstract Neuromodulation achieved by vagus nerve stimulation (VNS) induces various neuropsychiatric effects whose underlying mechanisms of action remain poorly understood. Innervation of neuromodulators and a microcircuit structure in the cerebral cortex informed the hypothesis that VNS exerts layer-specific […]

Vagus nerve stimulation intensities produce motor cortex reorganization

nathan whitmore and his rats

Link – A limited range of vagus nerve stimulation intensities produce motor cortex reorganization when delivered during training. Abstract Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to improve recovery after neurological injury, an effect ascribed to VNS-dependent enhancement of synaptic plasticity. Previous studies demonstrate that pairing VNS with forelimb […]

Rat vagus nerve stimulation parameters

Link – Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects. Abstract BACKGROUND: Recent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied VNS parameters. OBJECTIVE: To allow meaningful preclinical research on the mechanisms of VNS and translation […]