EEG-based classification of Epilepsy

Link – EEG-based classification of epilepsy and PNES: EEG microstate and functional brain network features. Abstract Epilepsy and psychogenic non-epileptic seizures (PNES) often show over-lap in symptoms, especially at an early disease stage. During a PNES, the electrical activity of the brain remains normal but in case of an epileptic seizure the brain will show […]

Circadian distribution of autostimulations in rVNS therapy

Link – Circadian distribution of autostimulations in rVNS therapy in patients with refractory focal epilepsy. Abstract BACKGROUND: Responsive vagus nerve stimulation (rVNS) utilizes an electrocardiograph (ECG)-based algorithm to detect rapid sympathetic activations associated with the onset of a seizure. Abrupt sympathetic activation may also be associated with nocturnal arousals between sleep cycles or transitioning from […]

The Efficacy and Safety of Rapid Cycling Vagus Nerve Stimulation

Link – The Efficacy and Safety of Rapid Cycling Vagus Nerve Stimulation in Children With Intractable Epilepsy. Abstract PURPOSE: Vagus nerve stimulation (VNS) is an effective adjunctive therapy for drug-resistant epilepsy. Nevertheless, information is lacking regarding optimization of stimulation parameters to improve efficacy. Our study examines the safety and efficacy of rapid duty cycle VNS […]

Desynchronization of theta during thalamus stimulation in epilepsy.

Link – Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy. Abstract BACKGROUND: Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help […]

Vagal Nerve Stimulation in Epilepsy

Link – Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits. Abstract Introduction: The purpose of this study was to examine patients’ experiences of vagal nerve stimulation (VNS) with a special interest in patients with cognitive deficit (CD). Materials and Methods: An open, retrospective study was conducted on 82 patients with pharmacoresistant epilepsy, […]

Rodent EEG: Expanding the Spectrum of Analysis.

Link – Rodent EEG: Expanding the Spectrum of Analysis. Abstract In epilepsy research, the analysis of rodent electroencephalogram (EEG) has been performed by many laboratories with a variety of techniques. However, the acquisition and basic analysis of rodent EEG have only recently been standardized. Since a number of software platforms and increased computational power have […]

tVNS Does Not Affect Verbal Memory Performance

Link – Transcutaneous Vagus Nerve Stimulation Does Not Affect Verbal Memory Performance in Healthy Volunteers. Abstract Introduction: Invasive vagus nerve stimulation (VNS) improves word recognition memory in patients with epilepsy. Recent studies with transcutaneous VNS (tVNS) have also shown positive effects on various subdomains of cognitive functioning in healthy volunteers. In this randomized, controlled, crossover […]

Epilepsy patients treated with Vagus Nerve Stimulation

Link – Neurophysiological investigations of drug resistant epilepsy patients treated with Vagus Nerve Stimulation to differentiate responders from non-responders. Abstract BACKGROUND: In patients treated with vagus nerve stimulation (VNS) for drug resistant epilepsy (DRE), up to 1/3 of patients will eventually not respond to the therapy. As VNS therapy requires surgery for device implantation, prediction […]

Modelling acute and lasting effects of tDCS on epileptic activity.

Link – Modelling acute and lasting effects of tDCS on epileptic activity. Abstract Transcranial Direct brain stimulation (tDCS) is commonly used in order to modulate cortical networks activity during physiological processes through the application of weak electrical fields with scalp electrodes. Cathodal stimulation has been shown to decrease brain excitability in the context of epilepsy, […]

The impact of sleep onset and offset on epileptiform discharges

Link – “Sleep Surge”: The impact of sleep onset and offset on epileptiform discharges in idiopathic generalized epilepsies. Abstract OBJECTIVE: To investigate the impact of sleep onset and offset on the rate of epileptiform discharges (ED) in idiopathic generalized epilepsies (IGE). METHODS: We studied the temporal distribution of EDs with mixed-effects Poisson regression modeling in […]