Dose-dependent effects of tACS

tDCS vs tACS

Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates.

Weak extracellular electric fields can influence spike timing in neural networks. Approaches to noninvasively impose these fields on the brain have high therapeutic potential in neurology and psychiatry. Transcranial alternating current stimulation (TACS) is hypothesized to affect spike timing and cause neural entrainment. However, the conditions under which these effects occur in vivo are unknown. Here, we recorded single-unit activity in the neocortex in awake nonhuman primates during TACS and found dose-dependent neural entrainment to the stimulation waveform. Cluster analysis of changes in interspike intervals identified two main types of neural responses to TACS-increased burstiness and phase entrainment. Our results uncover key mechanisms of TACS and show that the stimulation affects spike timing in the awake primate brain at intensities feasible in humans. Thus, novel TACS protocols tailored to ongoing brain activity may be a tool to normalize spike timing in maladaptive brain networks and neurological disease.

PMID: 32917605 [PubMed – as supplied by publisher]

Sci Adv. 2020 Sep;6(36):

Authors: Johnson L, Alekseichuk I, Krieg J, Doyle A, Yu Y, Vitek J, Johnson M, Opitz A




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