Effect of tACS on persistent delusions in schizophrenia.

Effect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia.

The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=12) with persistent delusions received add-on treatment with a twice-daily 20-minutes session of 10-Hz tACS. Significant reduction in severity of delusion was noted after 5th day (z=2.67, p<0.01, n=12) with further improvement after 10th day (z=2.52, p=0.01, n=9) of stimulation. Add-on treatment with 10-Hz tACS is a potential therapeutic option for treatment-resistant delusions, which requires further systematic research.

PMID: 32474070 [PubMed – as supplied by publisher]

Psychiatry Res. 2020 May 23;290:113106

Authors: Sreeraj VS, Suhas S, Parlikar R, Selvaraj S, Dinakaran D, Shivakumar V, Narayanaswamy JC, Venkatasubramanian G




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